The Promethease test is compatible with raw DNA data exports from Nebula Genomics, 23andMe, AncestryDNA, and other DNA testing companies. But, if you want specific, organized and actionable insights from your genetic data about your health and wellbeing, then you certainly must try the Xcode Health reports!! Promethease primarily focuses on Precision medicine and disease prediction. Biomedical researchers, healthcare practitioners and customers of DNA testing services (such as 23andMe , Ancestry.com , FamilyTreeDNA , Genos , etc.) I really want to use my raw data to find out if I suffer from a genetic disease or not. Both 23andme and Ancestry offer up a limited subset of genes for their customers. Disease risk is indicated as an average of all variants the individual carries and not a single variant. That wasn't terribly shocking as my maternal grandmother died from breast cancer. Xcode is pretty great. Not set: There is no verified information on the nature of the variation. How ActX differs from DNA raw data analysis sites like Promethease ActX has carefully validated the 23andMe raw data, and uses only probes that have been shown to work. In Greek mythology, Prometheus molded humanity out of clay and gave humanity fire to start their technological advancement. I purchased their nutrition analysis ($20) of my 23andme DNA raw data. Promethease Inc. is a popular service that will create a report for 17,000 of our 23,000 genes for only $5. How Does Genetics Influence Your Risk For Cockroach Allergy? These reports are focused and consumer-friendly and are designed specifically for practical use. How Does Genetics Influence Your Risk For Pet Allergy? Promethease will not accept my father’s raw data from FTDNA, due to the .csv.gz format. What's more, the oncology geneticist discovered I have another mutation in the VHL gene indicating von Hippel-Lindau syndrome. He is okay mentally, and still drives to wherever he feels like going. This is perhaps the most comprehensive take on Promethease. Xcode Life is a global genetic testing company, specializing in a variety of genetic reports such as Nutrition, Health, Fitness, Skin, Allergy, among several others using raw data from any Ancestry company. Typically files are ready within 1 hour. You can download your raw data, and these tips about how to get your data may be helpful, including for those using an ipad or iphone. Genetic Homeland Marker Index A free resource from Brad Larkin which provides an index of markers and their RSID positions on all 23 chromosomes. Even in the case of Monogenic conditions- where one single gene leads to disease, scientist have found individuals carrying these deadly mutations but apparently healthy with no sign of disease. This third party DNA raw data analysis tool, is a literature retrieval system from SNPedia which is a Wikipedia style repository where people can add information. Promethease. Promethease generates a report using genetic inform… However, if you want organized information that you can use in specific aspects of daily life such as Nutrition, Fitness, Personalized medicine, etc., to enhance your health and wellbeing, then you may not find the Promethease reports all that helpful. A lot of users come to Xcode after having tried Promethease for $5. Once you have your raw data, you can peruse it at leisure, without all the legal restrictions that affect what 23andme can and can’t tell you about yourself. Type: Literature Retrieval Service (connects directly to all scientific … There you have it! Even if one carries a disease variant, they may also be carrying variants that reduce the risk of disease. Promethease results are do-it-yourself. This website uses cookies to ensure you get the best experience on our website. Yeah, Promethease does mention the possibility of false positives, which is why confirmation is necessary! Promethease is a computer programme that was developed by SNPedia. As the name denotes, Ancestry.com is more focused on family lineage, whereas 23andme places a greater emphasis on health and wellness. GeneKnot A site which allows the user to upload genome data and compare DNA with other people with similar disease risks. Promethease or Codegen can take raw DNA data from the test results of AncestryDNA, 23andMe, FamilyTreeDNA, and other genetic testing companies. That is not true! You’re already doing so much to track your health. I was referred to an oncology geneticist and they ordered a test to confirm the results shown on Promethease using 23andme's raw data. However, it is important to realize that neither provider offers full genome sequencing. Once you organize the pages as per your unique needs it becomes a relatively easy task to. I was advised not to get the preventative surgeries just yet, but that may change in time as they learn more about my particular variant. Instead they “genotype.” While full genome sequencing looks at all your genes, genotypin… How Does Genetics Influence Your Risk For Contact Dermatitis? For example, for Alzheimer’s disease (AD), you will not get a summary of your risk for developing AD. Promethease is a do-it-yourself (DIY) tool for health genetic information from 23andMe raw data. You actually allow promethease.com to access the 23andme data by signing in … ➤23andMe ➤Ancestry.com ➤Family tree DNA ➤Genos ➤DNA land ➤Genes for Good ➤My Heritage ➤WeGene. All of mine were correct when I checked it under Promethease and when I opened raw file myself with Notepad++, I just Googled each one individually to see meaning of it inside the National medicine library government website. One such provider is Xcode Life which is a global genetics and bioinformatics company which specializes in 23andme raw data analysis and interpretation using genetic raw data from all major international data providers such as 23andme, Family Tree DNA (FTDNA), AncestryDNA.com, Helix.com, Living DNA, National Geographic and others . Example health, nutrition, fitness, Allergy etc. Since all of the formats from the various companies are just tab or CSV (.cvs) delimited, Promethease relies on these headers to … When the FDA (briefly) banned 23andme from providing health reports, Promethease was the only alternative and gained popularity because of its (almost) free service. You don’t need the expertise to interpret the results as they are expert-curated. All in all, I am extremely happy that I had the health portion of 23andme done, even though the results were incorrect when interpreted by Promethease. Codegen A free comprehensive health report using 23andMe raw data. The client came to me with her Promethease report already generated, having used a raw data file from 23andMe. After 23andme FDA ban on providing health reports, people started using tools like Promethease to get more information from their DNA raw data, other than just locating distant cousins. I'm pretty much guaranteed to get tumors/cancer, and there's no preventative surgeries for that, but at least we can increase surveillance and catch things early, so that's a good thing! Likewise, a Promethease report compiles all of the genetic variants found in your genetic data. ➤Nutrition ➤Fitness ➤Health, ➤Precision Medicine ➤Carrier Status ➤Skincare ➤Ancestry ➤Weight Loss ➤Methylation and detox analysis ➤Allergies ➤ Breast cancer and BRCA. Using a low-budget Web service called Promethease, she paid $5 to upload her raw 23andMe data. In a majority of the cases, the genetic risk is a small contributor towards the overall risk of that disease/condition. Talk about your genes and their possible implications! Cookies help us deliver our Services. Xcode reports are easily readable, understandable and implementable. Cost: $12 flat rate for analyses of individual data files, additional $4 per file if uploaded simultaneously. This is a simple introduction to the use of Promethease, a website which allows you to upload your raw DNA data (which can be obtained from the DNA testing company you sent your sample to – such as Ancestry, FTDNA, MyHeritage DNA or 23andMe), to receive a detailed report of biological traits and predispositions you carry within you.. At Promethease you can use your raw DNA from a variety of testing services (including 23andme and AncestryDNA) to receive health reports. More infoOkay! The report is topical. I DO NOT have the pathologic mutation I thought I had! ➤23andMe ➤ Ancestry.com ➤ Family tree DNA ➤ Genos ➤ DNA land ➤Genes for Good ➤My Heritage ➤WeGene ➤Helix.com ➤Living DNA ➤Ancestry.com ➤Living DNA ➤National Geographic and all other major international data providers. How Does Genetics Influence Your Risk For Egg Allergy? Several other notable and high scientific authority tools are left out from the Promethease reports. You can just use a large file editor like Notepad++ to view line by line all your Genes and Alleles. Good on you OP, you should always confirm these results by a geneticist. My 40th birthday is coming up soon and I decided it was time to start the process of getting preventative surgeries. Overview of Promethease. Below we present a feature by feature comparison between Promethease and Xcode Life Sciences. use Promethease to retrieve information published about their DNA … Common genotype; nothing interesting known. By using our Services or clicking I agree, you agree to our use of cookies. The editors her… Both sites can be used to upload raw data from other DNA testing companies to discover genetic variants which have been correlated to health information in scientific papers. You can get the Simplified Promethease report by clicking the banner on top of the page or using this link: https://www.xcode.life/product/ftdna-ancestrydna-23andme-raw-data-interpretation-analysis-tools. Promethease does not summarise these for you. These reports include all the information in 23andme’s report (you can see a full review of 23andme’s service here), and more—much more. Promethease is provided for personal use only. The results are presented in a modular way. You can search `genes/variants/diseases’ as you would in Wikipedia. Very detailed and thorough analysis of nutritional deficiency tendencies and my body’s response to macro and micro nutrients. Promethease is a literature retrieval system that builds a personal DNA report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia. A team of geneticists, genetic counselors, and pharmD’s carefully curates the variants and creates the content, which focuses on actionable items. Commercial users may request a license by contacting us. It uses your genetic raw data to give you largely disease based reports.You will get to know which mutation confers what risk. In this methodology, unless the individual truly carries a combination of several high-risk variants, their result will not be indicated as high risk. The chip versions used since then, and the … The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Digging deeper into a Promethease finding before accepting it as truth by Brianne Kirkpatrick, Watershed DNA, 11 September 2018. Our panels are also compatible with data from other consumer genomic … I also uploaded my data to Nebula and some traits both point out... Getting another test with Nebula in the hope that it will look different. I am not interested in knowing my risk of alzheimer's or other serious diseases like that where I can't do much to lower the risk. Did you also use GeneticGenie/Genvue with your 23andme file? Price: $12. It's a lot more than you will get from 23 and me. I noticed it showed I have a BRCA1 mutation. Promethease is popular as a low-cost offering, but it’s also very technical and disease-centric. However, there are several reports of panicked and confused Promethease users online. This report is based on genetic data from academic research aggregated on SNPedia.com — a database of single nucleotide polymorphisms (SNPs). To read your Promethease review report you will need to ensure that you are accustomed to some of the terms that are found in their report like magnitude and repute. DNA insights are an essential part of your health picture. Promethease.com and Codegen.eu are very similar sites. Here is the table partially resourced from the SNPedia website that describes what each numerical value indicates. The genetic raw data DNA interpretation and analysis services on this site require a 23andMe, AncestryDNA, MyHeritage, FTDNA (Family Tree DNA), Living DNA, HomeDNA, Genes for Good, WeGene (China), 23Mofang (China) raw data file or Whole Genome Sequence or Whole Exome Sequence VCF file. Take me to Raw Data … literature retrieval system that creates a personal DNA report based on your DNA data It is not a systematic risk assessment tool. I am looking at upload my 23AndMe raw data to Promethease. Their flagship product is a DNA health report. Promethease was one of the early companies to offer health reports based on 23andme data. Then the pandemic hit, and I didn't want to attend a lot of doctors appointments so I postponed taking action. The reports are on specific topics such as Nutrition, Allergy, skin, Fitness, health, precision medicine (drug sensitivity) and other topics. Promethease currently contains hundreds of thousands of raw DNA files uploaded by customers who have tested with services such as Ancestry.com, 23andMe, and FamilyTreeDNA. The report includes specific recommendations developed by a panel of experts. Client can delete their own information any time without having to secure permission from the company. If you cooked up your own file you may end up with a warning about it being unrecognized. Promethease only relies on SNPedia. So your 23andme Health results were correct in not detecting the variant, and this was just Promethease's interpretation of the raw file? You can use the Promethease 23andme sample to run your raw data through their program. Rather it returns all these 10 articles and makes you do the interpreting yourself. Please be aware that your report may cause you anxiety. For a particular disease or trait, if there are 15 articles that report on that particular DNA location, based on your SNPs 2 information sources might indicate an increased risk, 5 might be neutral, and 3 towards the lower side. Discord: https://discord.gg/uKKF38c, Looks like you're using new Reddit on an old browser. You don't actually need Promethease to see your gene information. Add personalized DNA insights for a more complete picture of your health.. Data you might already track: number of steps, hours slept, family history, and lifestyle choices. These reports come with DNA raw data analysis and interpretation and specific recommendations for people with your genetic type. Promethease does mention false positives are possible. Magnitude is a subjective parameter that measures the interest level of the information. So, one must consider all of these things in interpreting their report. As such, the data from 23andMe's Browse Raw Data feature is suitable only for research, educational, and informational use and not for medical, diagnostic or other use." I wouldn't have known about it had I not gotten the 23andme health test done. My father is close to 92 years old and lives a fairly active life (alone) and is in pretty darn good health. Many users try the Promethease reports due to the cost aspect. Whats the simplified prometheus and where can I get it? You get to know which variants you carry and the odds ratio of developing the specific disease. The vast majority of human traits are polygenic, meaning, several genes contribute towards that trait. Disease risk is communicated but no recommendations provided. Thanks for the article! Promethease does mention false positives are possible. A Promethease report is essentially a data dump, leaving the user to wade through a whole lot of science, statistics, charts, and graphs. It is a third party online tool that provides consumers information about their genetic variants and how they affect your health. Instead, you will get a list of scientific literature that is available that indicates or does not indicate your risk for AD for a specific variant. The report is not segregated based on topics. Promethease’s report includes thousands of results. Review of Promethease (www.promethease.com): Overview: This website matches your 23andMe, AncestryDNA, or other genetic data to the information on the Snpedia.com website. Promethease is probably the most popular but also the most confusing. 23andme only reports on certain variants, not all of them. Thank you for reading the article. Because 23andme actually collect and analyze your saliva sample, they are legally bound in how they present that data to you, in a way that other entities aren’t. This means that unless you are highly knowledgeable about the intricacies of SNPs and statistics, the process of interpreting their report can be cumbersome. 23andMe began offering direct-to-consumer genetic testing in 2007. Promethease’ emphasis largely seems to be the variety of different diseases that one can get. When you filter using this option you will find all the medical conditions that have been formally labeled by ClinVar. Bad repute: The variation has a negative influence on you. Regardless, a medical grade test is always the way to go to double-check. Reports: Provide links to SNPedia pages, a … Good repute: The variation has a positive influence on you. This is the major reason why many individuals are alarmed and confused by their Promethease report. Thanx, Hi Nicole! As an alternative to this third party tool, many people use 23andme raw data analysis and interpretation third-party tools and services. Whew! Regardless, a medical grade test is always the way to go to double-check. :). Many individuals carry risk variants that will not manifest in the form of a disease. How Does Genetics Influence Your Risk For Dust Mite Allergy? Nutrition, Fitness, Health, Allergy, Skin, Nutrition, Fitness, Health, Allergy, Skin, Precision Medicine, MTHFR, Nutrition, Fitness, Health, Allergy, Skin, Precision Medicine, MTHFR, Carrier Status, and Traits & Personality, © Copyright 2010-20 - Xcode Life - All Rights Reserved, Promethease and Xcode Life health reports: How to choose 23andme raw data health reports. My advice is get health results confirmed quickly rather than automatically accepting them as fact! Just upload your original untouched data. To store your data or use third-party interpretation services such as Genetic Genie, Self Decode, Promethease, Codegen, GEDmatch and more, you must download your raw DNA data first using a 23andMe login. Gave dietary suggestions for increasing intake of various vitamins and minerals and what to avoid/consider for weight loss. Looking at Promethease reviews titled Promethease vs 23andme health, can show you with Promethease can tell you. Her concern was for a possibly elevated risk for gastric cancer based on a finding that appeared at the top of her report. Completed reports can be regenerated at any time for no further cost. Promethease report will indicate that your risk for several diseases is several times higher than the normal population- be prepared! https://www.xcode.life/product/ftdna-ancestrydna-23andme-raw-data-interpretation-analysis-tools. This option allows you to see only the SNPs present in ClinVar. The Ancestry-only product from 23andMe produces exactly the same Promethease report as their Ancestry + Health product. Xcode Life provides all the information and much more, but there are key differences for you to note. You can obtain this additional service from promethease.com. Price: $12 – $16 Privacy policy : States that “At no time is your DNA data shared – or sold – to any external party, period. I took some time to sit with that information. However, the genetic testing did show I have a "variant of unknown significance" which requires further research. ClinVar is a freely accessible public archive of information on genetic variations specifically with clinical implications. Xcode Life, on the other hand, includes expert-curated references not just from SNPedia but also from several large and high scientific authority databases, including UK biobank, Clinvar, OMIM, and leading scientific journals to name a few,  to curate the variant annotations. Your Promethease … How Does Genetics Influence Your Risk For Milk Allergy? This video compares the aesthetic and functional aspects of 23andMe and Promethease test reports. If you just want to satisfy your curiosity and not really looking for anything specific, then Promethease may be the way to go. Counseling is also available, upon request. I received the results two days ago. I know many people will try to make use of their raw data anyway, so here is my guidance for the folks turning to Pomethease. I read up on my options and mentally prepared for the struggle ahead of me. The core philosophy of Xcode reports is to empower the user with actionable genetic information that they can use to enhance health and wellbeing. Promethease provides health report for $5 based on 23andme, Ancestry DNA, Family Tree DNA. Some of them are gene names, haplogroup names, diseases, drug names (referred to as “medicines”), medical conditions, names of genes and race. You have the common genotype; but varies for others. Promethease is a wiki-style collection of peer curated (not expert-curated) genetic information. That's a relief. The tool is equipped with different kinds of filters aimed at assisting you. Each report is further organized into traits, which provide actionable insights into your genetic type along with specific recommendations for you. How Does Genetics Influence Your Risk For Photic Sneeze? A lot of people think that getting the additional health report from 23andme will help them get better results. Xcode provides reports to individuals and professional practitioners such as physicians, surgeons, nutritionists, sports trainers, chiropractic and other professionals. DNA Data. So your 23andme Health results were correct in not detecting the variant, and this was just Promethease's interpretation of the raw file?
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